These chemicals are manufactured as coproducts and are used commercially in a large variety of applications. This public health statement is the summary chapter from the toxicological profile for propylene glycol. Propylene glycol dicaprylatecaprate crodamol pc crodamol pc dab 10 s. Propylene glycol used as an excipient european medicines agency. Other glycols are also used but monopropylene glycol is the most typically used. Uses the major use of propylene oxide is in the production of polyethers the primary component of polyurethane foams and propylene glycol. As a emulsifiers, propylene glycol e1520 can be used in a wide variety of industries including. Find patient medical information for systane propylene glycol ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Propylene glycol is an odorless, colorless liquid used in the manufacture of consumer and industrial products. Propylene glycol is unique among the glycols in that it is safe for humans to take internally. Pharmaceuticalgrade propylene glycol usp ep is used as a nonactive enabling agent, also known as. Workplace exposure exposure can occur in a propylene glycol manufacturing facility, during transport or in the various industrial. Epoxypropane propylene oxide forms on addition of a solution of either sodium hydroxide or calcium hydroxide. Find patient medical information for propylene glycolglycerin topical on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Practical uses for propylene glycol the chemistry store.
Dispose of surplus and nonrecyclable products via a. Only within the past few years has propylene glycol been used in a new. This list is strictly for informational purposes and a guideline to various detergent, cosmetic and coating formulations. Have victim rinse mouth with water, then give one to two glasses of water to drink. Ethylene glycol eg is colourless liquid with a sweet taste. Consumption of propylene glycol follows an erratic pattern in the united states which reflects domestic economic conditions. The high flash point, the high ignition temperature and a favorable toxicological profile make it a relatively safe. Mono propylene glycol, commonly referred to as propylene glycol but also referred to as propane1,2diol, mpg, pg and food safe glycol. This material and its container must be disposed of in a safe way. The personal care products council provided information regarding the. It is labeled an organic compound in chemistry due to its carbon attributes. Propylene glycol usp the generation of waste should be avoided or minimized wherever possible.
Propylene glycol also is produced by the liquidphase high pressure reaction 600 atmospheres of. The truth about propylene glycol, according to a chemist. Polyalkylene glycol monobutyl ether pgme for handling. Propylen glycol diacetate description dowanol pgda, propylene glycol diacet ate, is a highly pure chemical product more than 99. Propylene glycol is used as one of the three main ingredients in ecigarettes, along with nicotine and flavoring. It is a clear, colorless, practically odorless liquid with a comparatively high boiling point. Propylene glycol as a pharmaceutical excipient in pediatrics. Since an enormous quantity must be consumed before toxicity level is reached, it. Although it is considered relatively safe, multiple case reports have verified the association of propylene glycol. Like all ingredients, propylene glycol may produce adverse effects in the patient, but drastically less harmful than others. Never give anything by mouth to an unconscious person. Propylene glycol is also used to make polyester compounds and as a base for deicing solutions. Propylene glycol can also be used as a solvent in the manufacture of oral, topical applications and injections for the pharmaceutical industry, because it is insoluble in water. Table 5 gives a breakdown by percentage for the principal uses of propylene glycol in the united states.
Firstaid measures description of first aid measures do not induce vomiting. This chapter aims to provide a general overview of propylene glycol and its commercial uses. Industrialgrade propylene glycol is used in industries as a heattransfer medium that protects against. Propylene glycol has for many years been the goto glycol for use in food and beverage processing systems or where there is a requirement for a nontoxic classification. The uses of propylene glycol in daily life pharmaceutical uses. It is able to interfere with the hydrogen bonds in water, making it. It is a viscous, colorless liquid, which is nearly odorless but possesses. When dilute propylene glycol alginate solutions are adjusted to ph 9. Reactions include betaelimination, resulting in rapid depolymerization, and saponification of the ester groups to form ionized carboxyl groups.
It is added to food colorings and flavorings because of its sweet flavor combined with its solvent properties. Only within the past few years has propylene glycol been used in a new version of antifreeze that. Propylene glycol is used as a humectant e1520, solvent, and preservative in food and for tobacco products,propylene glycol used as emulsifiers preservatives in medicine manufacturing hygroscopic agents, antifreeze agents, lubricants and solvents in food production. Propylene glycol is produced commercially from the hydration of propylene oxide merck 1989. Propylene glycol often abbreviated pg has many applications. Propylene glycol is used as a chemical inter mediate in the manufacture of unsaturated polyester resins. The adm proprietary technology uses a catalytic process known as hydrogenolysis to readily convert glycerin into propylene glycol. The biotechnological production of propylene glycol has received a lot of attention in recent years. Based on the uses for propylene glycol, individuals could be exposed through. In cosmetics, mpg is used as an ingredient at concentra. The common name ethylene glycol literally means the glycol derived from ethylene. Last week, we took a look at the properties behind this highly toxic compound. Find patient medical information for propylene glycol glycerin topical on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Because of its versatility propylene glycol is used in a variety of applications in aqueous solutions and over a wide temperature range. Propylene glycol is commonly used as an excipient in a variety of drugs and it is also authorised in food products and cosmetics. Revision bulletin 2 propylene official february 1, 2010 ature is 250, and the column temperature is programmed at a rateprocedureinject a suitable volume, typically about 10 l, of of 5 per minute from 120 to 200, and helium is used as the car propylene glycol into a suitable gas chromatograph, and record the. With its multiple uses, propylene glycol is wellsuited for children for its safety and effectiveness. Propylene glycol is a synthetic liquid substance that absorbs water. It is mandatory to use propylene glycol uspep rather than propylene glycol industrialtechnical grade in such sensitive applications to avoid. We can ship the product from any of the seven warehouses located across. Propene is passed into liquid 1,1dimethylethyl hydroperoxide under pressure at about 400 k with a soluble molybdenum salt as catalyst. Propylene glycol is used extensively in these systems. The most common use of ethylene glycol is in antifreeze formulations.
Propylene glycol is used by the chemical, food, and pharmaceutical industries as an. Butylene glycol, hexylene glycol, ethoxydiglycol and dipropylene glycol are clear, practically colorless, liquids. Propylene glycol industrial grade pgi is a colorless, odorless and slightly viscous liquid. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. Propylene glycol intended for human use is designated as usp grade and is commonly found in foods, pharmaceuticals. Sigma aldrich offers a number of propylene glycol products. It is a viscous liquid that is sweet, faint and transparent. It was concluded that propylene glycol, all ppg currently in the international cosmetic ingredient dictionary and handbook, any ppgs added in the future, and tripropylene glycol are safe as used when formulated to be nonirritating. Propylene glycol is an organic compound with many industrial uses. Propylene glycol 1,2dihydroxypropane or 1,2propanediol or methyl glycol or trimethyl glycol is a clear liquid used in antifreeze and deicing solutions for cars, airplanes, and boats. Propylene glycol dipropylene glycol1 tripropylene glycol1 propylene glycols glycols chemistry centers on the two hydroxyl oh groups that characterize them as glycols. Propylene glycol has been designated by the fda as generally recognized as safe, or gras, for consumption.
Dow propylene glycol is used in the production of industrial and consumer products. Food and drug administration fda under 21 cfr x184. Dailymed systane ultra polyethylene glycol 400 and. The unsaturated dicarboxylic acid is typically maleic or fumeric acid and the saturated dicarboxylic acid is phthalic or isophthalic acid. Food and drug administration fda approves its use as an indirect food additive. Propylene glycol is approved and used as a vehicle for topical, oral and some. Empty containers or liners may retain some product residues. Ethylene glycol is the subject of a separate monograph. The fda along with other international standards institutions considers it to be generally safe to handle and to ingest and has certified the safety of using propylene glycol in medications, food flavors and for industrial purposes. Ethylene glycol, also called ethane1,2diol, the simplest member of the glycol family of organic compounds.
They, therefore, have intermediate properties between alcohols, with a single hydroxyl group and glycerine with its three hydroxyl groups. Propylene glycol is also present in propylene glycol alginate, which is known as e405. The primary use of ethylene glycol is for polyethylene terephthalate pet plastic resin used to make beverage containers for soda, water and juice, and polyester fiber for clothes, upholstery, carpet, and pillows. A glycol is an alcohol with two hydroxyl groups on adjacent carbon atoms a 1,2diol. This week, were talking about its many uses that stretch across a variety of different industries. Propylene glycol is a compound which is generally recognized as safe gras by the u. Another testament to the nontoxic nature of pg is its use in the food industry where it serves as a. It is one in a series of public health statements about hazardous substances and their health effects. Propylene glycol is a common vehicle for many drugs, including topical silver sulfadiazine and intravenous preparations of nitroglycerin, diazepam, lorazepam, phenytoin, etomidate, and trimethoprimsulfamethoxazole, among others.
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